Cosine Colorization for Enhancement of Magnetic Resonance Angiography (MRA)
Modupe Odusami, Robertas Damaševičius, Olusola Abayomi-Alli, Rytis Maskeliūnas
DOI: http://dx.doi.org/10.15439/2026F8443
Citation: Modupe Odusami, Robertas Damaševičius, Olusola Abayomi-Alli, Rytis Maskeliūnas (2026). Cosine Colorization for Enhancement of Magnetic Resonance Angiography (MRA). In M. Bolanowski, M. Ganzha, M. Grzegorowski, L. Maciaszek, M. Paprzycki, A. Paszkiewicz, D. Ślęzak (eds), Proceedings of the 21st Conference on Computer Science and Intelligence Systems (FedCSIS). ACSIS, Vol. 49, pages 81–88.
Abstract. Non-invasive imaging modalities play a crucial role in healthcare. The use of Magnetic Resonance Angiography (MRA) has enhanced access to blood vessel information. MRA grayscale preserves anatomical fidelity but offers limited perceptual separation. This study investigates the use of cosine colorization to enhance feature discrimination in MRA. The cosine colorization utilizes the Frangi vesselness filter combined with statistical thresholding to isolate vascular regions. Quantitative and statistical evaluations were conducted on 20 MRA volumes, comparing grayscale baselines with full-volume and vessel-restricted cosine mappings. While full-volume colorization introduces structural distortion (SSIM ≈ 0.85 and NMSE ≈ 0.018), the vessel-restricted approach maintains near-perfect anatomical fidelity (SSIM ≈ 1.0 and NMSE ≈ 0). Statistical analysis confirms significant improvements in perceptual separability (p < 10−5) without degradation of structural metrics for the vessel-restricted cosine approach. The results show that the vessel-restricted cosine approach provides an interpretable enhancement of vascular structures.
References
- Gadhave DG, Sugandhi VV, Jha SK, Nangare SN, Gupta G, Singh SK, Dua K, Cho H, Hansbro PM, Paudel KR. Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance. Ageing research reviews. 2024 Aug 1;99:102357, https://doi.org/10.1016/j.arr.2024.102357.
- Rezaei M, Mohammadikhaveh S, Faraji H, Ardalani R, Rezaei M, Shirazinodeh A. Early diagnosis of Alzheimer’s disease based on brain morphological changes: A comprehensive approach combining voxelbased morphometry and deep learning. NeuroImage: Reports. 2026 Mar 1;6(1):100315, https://doi.org/10.1016/j.ynirp.2025.100315.
- BAlsabti SM, Al-Gburi RM, Mustafa A, AHMED SK, Issa AM, Al-Naimi TM, AlSaad R, Elhenidy AM. Advances in Deep Learning for Multimodal Brain Imaging: A Comprehensive Survey. Neuroscience Informatics. 2025 Dec 19:100252, https://doi.org/10.1016/j.neuri.2025.100252.
- Karthikeyan S, Muthu Kumar B, Kiran ML, Srivatsan K. Computational Brain Imaging Framework for Neurological Mapping and Disorder Classification Using Multimodal Image Processing. International Journal of Computational Intelligence Systems. 2025 May 19;18(1):121, https://doi.org/10.1007/s44196-025-00852-1.
- Ricci M, Cimini A, Chiaravalloti A, Filippi L, Schillaci O. Positron emission tomography (PET) and neuroimaging in the personalized approach to neurodegenerative causes of dementia. International Journal of Molecular Sciences. 2020 Oct 11;21(20):7481, https://doi.org/10.3390/ijms21207481.
- Ansari AS, Mohammadi MS, Cattani C, Tassaddiq A. An advanced multimodal image fusion model for accurate detection of Alzheimer’s disease using MRI and PET. Frontiers in Medical Technology. 2025 Dec 2;7:1699821, https://doi.org/10.3389/fmedt.2025.1699821.
- Bhattacharya S, Prusty S, Pande SP, Gulhane M, Lavate SH, Rakesh N, Veerasamy S. Integration of multimodal imaging data with machine learning for improved diagnosis and prognosis in neuroimaging. Frontiers in Human Neuroscience. 2025 Mar 21;19:1552178, https://doi.org/10.3389/fnhum.2025.1552178.
- Zubair M, Hussain M, Al-Bashrawi MA, Bendechache M, Owais M. A comprehensive review of techniques, algorithms, advancements, challenges, and clinical applications of multi-modal medical image fusion for improved diagnosis. Computer Methods and Programs in Biomedicine. 2025 Sep 9:109014, https://doi.org/10.1016/j.cmpb.2025.109014.
- Calhoun VD, Sui J. Multimodal fusion of brain imaging data: a key to finding the missing link (s) in complex mental illness. Biological psychiatry: cognitive neuroscience and neuroimaging. 2016 May 1;1(3):23044, https://doi.org/10.1016/j.bpsc.2015.12.005.
- Mathur AN, Khattar A, Sharma O. 2D to 3D medical image colorization. InProceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision 2021 (pp. 2847-2856), https://doi.org/10.1109/WACV48630.2021.00289.
- Odusami M, Damasevicius R, Milieskaite-Belousoviene E, Maskeliunas R. Multimodal neuroimaging fusion for Alzheimer’s disease: an image colorization approach with mobile vision transformer. International Journal of Imaging Systems and Technology. 2024 Sep;34(5):e23158, https://doi.org/10.1002/ima.23158.
- Pei E. Ambient Environment Effect on Color Perception. Rochester Institute of Technology; 2025.
- Costanzo L, Failla G, Aluigi L, Baroncelli TA, Bua C, De Marchi S, Diaco E, Di Paola F, Di Pino FL, Mannello F, Martinelli O. Operative Procedures for Ultrasound Assessment of Extracranial Artery Disease: A Narrative Review by the Italian Society for Vascular Investigation (SIDV). Journal of Clinical Medicine. 2025 Oct 6;14(19):7050, https://doi.org/10.3390/jcm14197050.
- Alfadeel H. Impact of CT Stroke Window Settings on Acute Stroke Detection. Scientific Journal of University of Benghazi. 2025 Jun 29;38(1):193-214, https://doi.org/10.37376/sjuob.v38i1.7328.
- D’Angelo T, Mastrodicasa D, Lanzafame LR, Yel I, Koch V, Gruenewald LD, Sharma SP, Ascenti V, Micari A, Blandino A, Vogl TJ. Optimization of window settings for coronary artery assessment using spectral CTderived virtual monoenergetic imaging. La radiologia medica. 2024 Jul;129(7):999-100 7, https://doi.org/10.1007/s11547-024-01835-6.
- Mohammad NI. Hierarchical Spatial Algorithms for HighResolution Image Quantization and Feature Extraction. arXiv preprint https://arxiv.org/abs/2510.08449. 2025 Oct 9, https://doi.org/10.1049/ietipr.2019.0921.
- Singh N, Bhandari AK. Image contrast enhancement with brightness preservation using an optimal gamma and logarithmic approach. IET Image Process 14 (4): 794–805 [Internet]. 2019
- Sarkar K, Halder TK, Mandal A. Adaptive power-law and cdfbased geometric transformation for low-contrast image enhancement. Multimedia Tools and Applications. 2021 Feb;80(4):6329-5 3, https://doi.org/10.1007/s11042-020-10004-6
- Khan MA, AlGhamdi MA. An intelligent and fast system for detection of grape diseases in RGB, grayscale, YCbCr, HSV, and L*a*b* color spaces. Multimedia Tools and Applications. 2024 May;83(17):50381-99, https://doi.org/10.1007/s11042-023-17446-8
- Mookiah S, Parasuraman K, Kumar Chandar S. Color image segmentation based on improved sine cosine optimization algorithm. Soft Computing. 2022 Dec;26(23):13193-203, https://doi.org/10.1007/s00500022-07133-5
- Reinhold JC, Dewey BE, Carass A, Prince JL. Evaluating the impact of intensity normalization on MR image synthesis. In Proceedings of SPIE—the International Society for Optical Engineering, 2019 Mar (Vol. 10949, p. 109493H), https://doi.org/10.1117/12.2513089.
- Johnson R. A review of three-dimensional medical image visualization. Health Data Science. 2022(1):83-101, https://doi.org/10.34133/2022/9840519.
- Longo A, Morscher S, Najafababdi JM, Jüstel D, Zakian C, Ntziachristos V. Assessment of a Hessian-based Frangi vesselness filter in optoacoustic imaging. Photoacoustics. 2020 Dec 1;20:100200, https://doi.org/10.1016/j.pacs.2020.100200
- Sheethal. M. S, Amudha P. Enhanced Brain Tumor Detection via Multiscale Frangi Gaussian Matrix and Efficient Convolutional Networks on MRI. J. Inf. Hiding Multim. Signal Process. 2024 Sep;15(4):236-70.
- Qin B, Jin M, Hao D, Lv Y, Liu Q, Zhu Y, Ding S, Zhao J, Fei B. Accurate vessel extraction via tensor completion of background layer in X-ray coronary angiograms. Pattern recognition. 2019 Mar 1;87:38-54, https://doi.org/10.1016/j.patcog.2018.09.015.
- Zhang M, Wang J, Cao X, Xu X, Zhou J, Chen H. An integrated global and local thresholding method for segmenting blood vessels in angiography. Heliyon. 2024 Nov 30;10(22), https://doi.org/10.1016/j.heliyon.2024.e38579.
- Recommendation IT. Colour conversion from Recommendation ITU-R BT. 709 to Recommendation ITU-R BT. 2020. Geneva: ITU-R. 2015.